The Novel Trends in Data Science 2023 workshop will be held at the beautiful conference center Congressi Stefano Franscini (CSF) at Monte Verità in Ticino, Switzerland, from October 22-25, 2023. It aims to bring together researchers from mathematics and computer science and related fields to discuss and showcase the latest advancements in Data Science across the entire data analytics pipeline – from data management, integration, and curation, to mathematical/ statistical data analysis and machine learning. We also solicit contributions reporting on innovative applications in Data Science.